In thrombolytic therapy by Urokinase (UK), standards for the mode and amount of UK administration Ina--ve not yet been established in Japan. In particular, the efficular
In thrombolytic therapy by Urokinase(UK), standards for the mode and amount of UK administration have not vet been established in Japan. In paticular, the efficacy of small dose administration, which is -a popular method of administering UK, has been questioned. In the present studies, the metabolism of UK´ was investigated with regard to the plasma fibrinolytic activity, which is essential for effective thrombolysis.´
The results indicated the operation of threshold phenomena and a latent time for the appearance of fibrinolytic activity in the plasma, and the inactivation rate constant of uk changed on the ;apperance of fibrinolytic activity. These results were explained with a. two compartment model for UK metabolism. Basedon this method, concomitant use was made of one-shot and infusion adminstrations of UK, and this program was succeful in inducing fibrinolytic activity from the outset of UK administration. The amount of UK given by such concomitant administration was thus of the large dose category.. Clearly, concomitant use of one shot and infusion administrations of UK may well be useful clinically for inducing effective thrombolysis.
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